Bove FJ, Fulcomer MC, Klotz JB, Esmart J, et al. 15. Inhalation of more than 50 ppm (parts per million) trichloroethylene can produce acute effects on the body, including nausea and vomiting, eye and throat irritation, dizziness, headache, and liver, heart, or neurological damage. Maternal exposure to trichloroethylene in drinking water and birthweight outcomes. Inadequately protected workers can also inhale TCE fumes when working with products containing this toxic chemical. Environ Health Perspect 117:696–702. 26; 677-685. As a solvent or as a component of solvent blends trichloroethylene is used with adhesives, lubricants, paints, varnishes, paint strippers, pesticides, and cold metal cleaners. Studies have shown that simultaneous alcohol consumption and trichloroethylene inhalation increases the toxicity of trichloroethylene in humans. Long Term Effects: Exposure to trichloroethylene in the workplace may cause scleroderma (a systemic autoimmune disease) in some people. Trichloroethylene--a review of the literature from a health effects perspective. Vernot EH, MacEwen JD, Haun CC, Kinkead EK [1977]. Wartenberg D, Reyner D, Scott CS. 29:220-229. 15:445-452. 10. Khattak S, K-Moghtader G, McMartin K, Barrera M, et al. Boston, Massachusetts: Massachusetts Department of Public Health. If you need further information regarding the health effects of trichloroethylene, please contact the Virginia Department of Health, Office of Environmental Health Services, 109 Governor Street, 5th Floor, Richmond, VA 23219, or call (804) 864-8182. The current state of knowledge related to TCE health effects show the clear potential to induce cancer in humansand it does not allow us to establish a certain TCE dose above which the cancer risks will be eliminated. Health Effects. 2007. When you are exposed (during pregnancy, in infancy, etc), How you are exposed (breathing, drinking), and. Short Review: Benzene’s toxicity: a consolidated short review of human and animal studies. 8:679-680. 0.2.1.1 ACUTE EXPOSURE. Acquisition of additional data in the following areas would enable a more complete evaluation of the potential effects to the health of the general population in Canada. Sacramento, California. Special emphasis is given to the health effects reported in excess of national norms by participants in the TCE Subregistry of the Volatile Organic Compounds Registry of the National Exposure Registries — persons with documented exposure to TCE through drinking and use of contaminated … 2007. 13. 1999. Special emphasis is given to the health effects reported in excess of national norms by participants in the TCE Subregistry of the Volatile Organic Compounds Registry of the National Exposure Registries--persons with documented exposure to TCE through drinking and use of contaminated water. Grosse Y, Baan R, Straif K, Secretan B, et al. Environ Health Perspect 111(2):167-73. Sections I (Health Hazard Assessments for Noncarcinogenic Effects… You may also call your local health department if you have questions or concerns. 1. 6. INTRODUCTION The Health Advisory (HA) Program, sponsored by the Office of Drinking Water (ODW), provides information on the health effects, analytical method- ology and treatment technology that would be useful in dealing with the contamination of drinking water. JAMA 281(12): 1106-09. While trichloroethylene (TCE) is not found naturally, it can contaminate water sources and be ingested. Pesticide and Environmental Toxicology Section, Office of Environmental Health Hazard Assessment, California Environmental Protection Agency. Public drinking water contamination and birth outcomes. Environ Res 93:248-258. Conclusions cannot be drawn from the limited studies available. 9. Repeated (chronic) or prolonged exposure to TCE ha… Chonal atresia (nasal passages blocked with bone or tissue) (1, 2), Oral cleft defects (including cleft lip) (, Neurological effects (delayed reaction times problems with short-term memory, visual perception, attention, and color vision) (, Neurobehavioral performance deficits (i.e., delayed recall and deficits in visual perception), decreased blink reflex, and mood effects (i.e., confusion, depression and tension) (, Severe, generalized hypersensitivity skin disorder (an autoimmune-related disease) (. What your personal traits and habits are. This report reviews the literature on the impact of exposure to trichloroethylene (TCE) on human health. Findings from ATSDR’s health studies at Camp Lejeune are available at https://www.atsdr.cdc.gov/sites/lejeune/activities.html. 2. Cancer Causes Control. Evidence of autoimmune-related effects of trichloroethylene exposure from studies in mice and humans. Rodenbeck SE, Sanderson LM, Rene A. 2009. Human health effects of trichloroethylene: key findings and scientific issues. 2013. Meta-analysis of studies of occupational exposure to vinyl chloride in relation to cancer mortality. Trichloroethylene has a long list of potentially hazardous health effects. An increased risk of developing autoimmune diseases is one of the most consistently reported adverse health effects of TCE . March 31, 1987 TRICHLOROETHYLENE Health Advisory Office of Drinking Water U.S. Environmental Protection Agency I. Effects of trichloroethylene on visual-motor performance. Environ Health Perspect 108(S2):161-176. Additionally, listed below are other health effects that have been linked to TCE, PCE, benzene, and/or vinyl chloride in populations other than Camp Lejeune who worked with and/or drank water contaminated with these chemicals. Listed below are the health effects where there is sufficient evidence for causation in people exposed occupationally or environmentally to the chemicals detected in the drinking water at Camp Lejeune. You will be subject to the destination website's privacy policy when you follow the link. Tetrachloroethylene-contaminated drinking water in Massachusetts and the risk of colon-rectum, lung, and other cancers. 2004. Workers may be harmed from exposure to trichloroethylene. 21. Hum Exp Toxicol. These effects may be mediated by trichloroethylene acting as a positive allosteric modulator of inhibitory GABAA and glycine receptors. 2000. hތ��n��_e.e��� $Ӳ�N *Q��\�ɵL�"rXo����YYT���{�P]]�����Ln�u�M%N>穤)�:�5mۣgp�����ScK�7W�rv���~��tw�n�����wO�����������w���8��~����W�{������x}�����������㓧Ww?��]|x����Nӓ�=O.��}ʻo_�_�S6vw��߿8\���8�w燱��������Ô�>Ϟ��6]|���ǖ��b����o>>������~���>L����\ċ�_�”����O�w�ݳo~x��oc��=���x8^��I��7������qs}�����ar����ݿ�^��X�=����w�^���ų�Á%~�� �/o��bLN/�_�}�������&�������H��-~>�� ��'wof7��T�%NI�R�e/m.EF��B_��|�e�N-L�籩�ц��>�f�e��ٸ�P�i�Ӝ��f���.B�K=RQ,��Tc���^N5�V���Tk���h9&k�����I�E3ȥD��d��1km�sS�I4�G. Single (acute) or short-term exposure can potentially affect the developing fetus. 16. Many types of cardiac arrhythmias can occur and are exacerbated by 4. Critical review of the epidemiological literature on occupational exposure to perchloroethylene and cancer. Pesticide and Environmental Toxicology Section, Office of Environmental Health Hazard Assessment, California Environmental Protection Agency. More research is needed to clearly show that the exposure causes the health effect. Chiu WA, Jinot J, Scott CS, Makris SL et al. Therefore, not everyone who is exposed to trichloroethylene (TCE), tetrachloroethylene (PCE), benzene, or vinyl chloride exposure will develop a health problem. Public health goal for tetrachloroethylene in drinking water. Carcinogenicity of 1,3-butadiene, ethylene oxide, vinyl chloride, vinyl fluoride, and vinyl bromide. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. HOW TRICHLOROETHYLENE ENTERS AND AFFECTS YOUR BODY TESTS FOR EXPOSURE AND MEDICAL EFFECTS LEGAL EXPOSURE LIMITS REDUCING YOUR EXPOSURE Health Hazard Summary: Trichloroethylene mainly affects the central nervous system (the brain), causing headache, nausea, dizziness, clumsiness, drowsiness, and other effects like those of being drunk. Gist GL(1), Burg JR. A) GENERAL - Trichloroethylene (TCE) is toxic by ingestion, inhalation or dermal exposure. Its symptoms are similar to those of alcohol intoxication, beginning with headache, dizziness, and confusion and progressing with increasing exposure to unconsciousness. Exposure to TCE raises a number of health effects concerns, including for effects in the developing fetus from both acute and chronic exposure. National Toxicology Program (NTP). CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Scand J Work Environ Health. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol 97: 1,3-Butadiene, Ethylene Oxide and Vinyl Halides (Vinyl Fluoride, Vinyl Chloride and Vinyl Bromide). Also, in assessing the entry, exposure, and effects of trichloroethylene on the environment, several data gaps have been identified. Evidence is considered sufficient for causation if there is 1) sufficient evidence from human studies in which chance and biases (including confounding) can be ruled out with reasonable confidence or 2) less than sufficient evidence from human studies but sufficient evidence in animal studies and strong evidence that the chemical acts through a relevant mechanism in humans. Arch Environ Health 18(6):894-900. Public health goal for trichloroethylene in drinking water. Environ Health Perspect 121:303-311. Oncology: The Lancet. Exposure to TCE can result in a number of health problems, including respiratory difficulties, liver damage, and even death. The effects of exposure to any chemical depend on—. Evidence of Autoimmune-Related Effects of Trichloroethylene Exposure from Studies in Mice and Humans. Scelo G, Constantinescu V, Csiki I, Zaridze D, et al. In particular, an association between TCE (as well other organic solvents) and systemic sclerosis has been replicated by many studies, and this association has recently been reviewed [35] , [36] . Trichloroethylene and cancer: epidemiologic evidence. Environ Health Perspect 110(S): 61-73. Occupational exposure to vinyl chloride, acrylonitrile and styrene and lung cancer risk (Europe). Reif JS, Burch JB, Nuckols JR, Metzgar L, et al. Crossref, Medline, Google Scholar; Cooper GS, Makris SL, Nietert PJ, Jinot J. Trichloroethylene exposure has been linked to Parkinson disease. 1996. TCE vapor may be irritating to the nose and throat. This report reviews the literature on the impact of exposure to trichloroethylene (TCE) on human health. Neurological Effects Health effects with sufficient evidence for causation for TCE. Blink reflex latency after exposure to trichloroethylene in well water. 1995. 12. Trichloroethylene (TCE) is a stable, low-boiling, colorless, photo reactive liquid with a chloroform-like odor. TrichloroethyleneHealth Effects on Respiratory system: It stimulates respiration causing tachypnoea. It has also been found to be carcinogenic when low level exposure continues long term. 2000. Sacramento, California. 0.2.1 SUMMARY OF EXPOSURE. Cardiac dysrhythmias may be induced by heavy TCE exposure. CNS effects; decreased appetite; gastrointestinal irritation; headaches; mucous membrane; skin irritation; Hepatotoxicity has been associated primarily with TCE inhalation and ingestion of very large amounts. 2003. Environ Health Perspect 107(4):265-71. Discussion will focus on different kinds of modeling and how they may be used Feldman RG, Chirico-Post J, Proctor SP. 20. At low concentrations it is relatively non-irritating to the respiratory tract. Mundt KA, Birk T, Burch MT. Public drinking water contamination and birth outcomes. Effects of Long-Term (Chronic) Exposure: Commercial trichloroethylene contains stabilizers, which may contribute to toxicity. A recent analysis of available Am J Epidemiol 141:850-62. In other words, equipoise and above means that there is enough research to support a link between the health effect and the exposure, but there is not enough research to definitively conclude that exposure causes the health effect. 3. Inhalation of TCE can cause euphoria, hallucinations and distorted perceptions; inhalational abuse, with addiction, has been reported. Int Arch Occup Environ Health. Can cause dry, red, cracked skin (dermatitis) following skin contact. Renal failure has been reported in concert with confirmed hepatic damage. An 8-hour exposure (two 4-hour exposures separated by 1.5 hours) to 110 ppm TCE for two 4-hr periods resulted in decreased performance on tests of perception, memory, reaction time, and dexterity.” The trichloroethylene health effects of chronic exposure paint a darker picture. Listed below are the health effects where the evidence is sufficient to conclude that a causal relationship is at least as likely as not, but not sufficient to conclude that a causal relationship exists (“equipoise and above”) in people exposed occupationally or environmentally to the chemicals detected in the drinking water at Camp Lejeune. Bove F, Shim Y, Zeitz P. 2002. Some evidence suggests that it may be associated with an increased risks of non-Hodgkin lymphoma and, possibly, liver cancer . 2009. Exposure to high concentrations can cause dizziness, headaches, sleepiness, confusion, nausea, unconsciousness, liver damage, and even death. 22. The chlorinated hydrocarbon trichloroethylene (TCE) is used extensively in industry as an anesthetic and solvent, thus, this chemical has caused various harmful effects in human beings. 19. 14th edition. 1988. Trichloroethylene; CASRN 79-01-6 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data, as outlined in the . Its high blood solubility results in a less desirable slower induction of anesthesia. 2003. Trichloroethylene (TCE) is a man-made chemical that can be a liquid or gas. Background: In support of the Integrated Risk Information System (IRIS), the U.S. Environmental Protection Agency (EPA) completed a toxicological review of trichloroethylene (TCE) in September 2011, which was the result of an effort spanning > 20 years. 5. 17. Cooper GS, Makris SL, Nietert PJ, Jinot J. The health effects of trichloroethylene depend on how much trichloroethylene you are exposed to and the length of that exposure. 10. 11. Trichloroethylene is primarily used as a solvent to remove greases from metal parts. Trichloroethylene effects on gene expression during cardiac development. Neurobehavioral effects of exposure to trichloroethylene through a municipal water supply. Until our knowledge will permit the acknowledgment of such dose, all we can do to protect human health is to consider that the presence of TCE may be harmful in any amount and our goal shoul… Reproductive Health Effects: A number of studies have suggested a linkage between TCE exposure and birth defects. IRIS assessment development process. %PDF-1.6 %���� This document combined the findings from ATSDR’s Camp Lejeune studies with findings from studies of other populations exposed occupationally or environmentally to TCE, PCE, vinyl chloride and benzene. Protection Agency (EPA) completed a toxicological review of trichloroethylene (TCE) in September 2011, which was the result of an effort spanning > 20 years. Author information: (1)Exposure and Disease Registry Branch, Agency for Toxic Substances and Disease Registry, Atlanta, Georgia 30333, USA. Toxicol Appl Pharmacol 42:417-423. 1999. 7. 8. Environ Health 43: 143-148. B jectives: We summarized the key findings and scientific issues regarding the human health effects of TCE in the U.S. EPA’s toxicological review. Drinking water contaminants and adverse pregnancy outcomes: a Review. Trichloroethylene may cause irritation to the eyes and skin. May harm the nervous system. 2001. Objectives: We summarized the key findings and scientific issues regarding the human health effects of TCE in the U.S. EPA's toxicological review. Pregnancy outcome following gestational exposure to organic solvents: a prospective controlled study. Kidney cancer; Non-Hodgkin lymphoma; Cardiac defects; Health effects with sufficient evidence for causation for PCE: Bladder cancer; Health effects with sufficient evidence for causation for benzene: Leukemias; Non-Hodgkin lymphoma When inhaled, trichloroethylene produces central nervous system depression resulting in general anesthesia. Report on carcinogens. Massachusetts Department of Public Health, Centers for Disease Control and Prevention, Massachusetts Health Research Institute. 2003. Agency for Toxic Substance and Disease Registration, Health effects with sufficient evidence for causation for TCE, Health effects with sufficient evidence for causation for PCE, Health effects with sufficient evidence for causation for benzene, Health effects with sufficient evidence for causation for vinyl chloride, Health effects with evidence that is equipoise and above for causation for TCE, Health effects with evidence that is equipoise and above for causation for PCE, Health effects with evidence that is equipoise and above for causation for benzene, Health effects with positive findings in at least one study that evaluated exposure to TCE and/or PCE, Health effects with positive findings in at least one study that evaluated exposure to benzene, Health effects with positive findings in at least one study that evaluated exposure to vinyl chloride, ATSDR Assessment of the Evidence for the Drinking Water Contaminants at Camp Lejeune and Specific Cancers and Other Diseases, https://www.atsdr.cdc.gov/sites/lejeune/activities.html, Agency for Toxic Substances and Disease Registry, Community Assistance Panel (CAP) and Media, U.S. Department of Health & Human Services. When inhaled, trichloroethylene can cause headaches, dizziness, poor coordination, and potentially unconsciousness (similar effects as intoxication). Perchloroethylene-contaminated drinking water and the risk of breast cancer: additional results from Cape Cod, Massachusetts, USA. 18. Effects to the liver, kidneys, and immune and endocrine systems have also been seen in humans exposed to trichloroethylene occupationally or from contaminanted drinking water. Bofetta P, Matisane L, Mundt KA, Dell LD. Am J Epidemiol 141:850-62. Physiological effects When inhaled, trichloroethylene, as with any anesthetic gas, depresses the central nervous system. trichloroethylene can affect the human central nervous system (CNS), with symptoms such as dizziness, headaches, confusion, euphoria, facial numbness, and weakness. ATSDR assessed 16 diseases in its document ATSDR Assessment of the Evidence for the Drinking Water Contaminants at Camp Lejeune and Specific Cancers and Other Diseasespdf icon. Birth Defects Res A Clin Mol Teratol 67:488-495 14565619. Breathing TCE vapor, especially at high levels or over long periods of time, can cause negative health effects. Prolonged or repeated exposure of trichloroethylene causes kidney cancer. Paulu C, Aschengrau A, Ozonoff D. 1999. As one might expect given its long term use as an anesthetic, one of the more prominent symptoms of TCE exposure is nervous system depression, eventually leading to a state of anesthesia. 14. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. Lyon, France 2008. Final report of the Woburn environmental and birth study. A comprehensive overview of the effects of trichloroethylene toxicity caused by real-life exposure levels highlighting how exposure to trichloroethylene may contribute to the etiology of several idiopathic human diseases. 85 0 obj <>stream 1995. High acute concentrations of TCE vapors can irritate the respiratory system and skin and induce central nervous system effects such as light-headedness, drowsiness, and headaches. Khan HA. Arch Environ Health 55:188–194. 76:473-91. Acute toxicity and skin corrosion data for some organic and inorganic compounds and aqueous solutions. Research Triangle Park, NC: US Department of Health and Human Services; 2016. The most serious health effect of TCE is its carcinogenic effect (capacity to induce cancer in humans). This report reviews the literature on the impact of exposure to trichloroethylene (TCE) on human health. Trichloroethylene is a known carcingen. Bove FJ, Fulcomer MC, Klotz JB, Esmart J, et al. Higher concentrations result in tachypnea. These links are based on studies with positive associations between exposures to these chemicals and development of health effects. Aschengrau A, Rogers S, Ozonoff D. 2003. Liver, kidney, immunological, endocrine, and developmental effects have also been reported in humans. TCE is carcinogenic to humans by all routes of exposure. Trichloroethylene: health effects, incident management and toxicology Information on trichloroethylene (also known as trichloroethene), for use in responding to chemical incidents. Trichloroethylene may cause irritation to the nose and throat, Zeitz P. 2002 dysrhythmias... Park, NC: US Department of Public health, Centers for Disease Control and Prevention ( CDC ) not!, low-boiling, trichloroethylene health effects, photo reactive liquid with a chloroform-like odor paulu C, aschengrau,... Any chemical depend on— toxic chemical by all routes of exposure to TCE raises a number of and... Distorted perceptions ; inhalational abuse, with addiction, has been reported in humans ;... And other cancers compounds and aqueous solutions, colorless, photo reactive liquid a. 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